What is Ephedrine HCL?
Ephedrine Hydrochloride 15mg Tablets
Ephedrine hydrochloride 15mg
White, circular tablets marked E15 on one face and CP on the reverse.
Ephedrine is a natural substance contained in some herbs. Ephedra known as Ma Huang contains ephedrine. Ephedra sinica known in Chinese as Ma Huang. This herb has been used in the traditional Chinese medicine for more than 5,000 years for the treatment of hay fever and asthma. This plant contains also pseudoephedrine. Ephedrine is contained in Sida Cordifolia’s leaves. Sida cordifolia native to India but spread to Africa, Australia, United States etc… It contains ephedrine and pseudoephedrine, but less than 2% found in the leaves.
Ephedrine is a sympathomimetic amine. Amine is an organic compound containing a basic nitrogen atom, derivative of ammonia. Sympathomimetic means that this amine is producing physiological effects analog to those caused by the sympathetic nervous system, which is a part of the nervous system originating in the thoracic and lumbar regions of the spinal cord. In this case it inhibits the physiological effects of another part of the nervous system, tending to reduce digestive secretions, speed up the heart, and contract the blood vessels.
Ephedrine and pseudoephedrine are alkaloids which is defined as naturally occurring chemical compounds that contain mostly basic nitrogen atoms (cf. amine). Alkaloids are often used as medications or drugs due to their pharmacological effects. In this large group we have the very well known caffeine, nicotine, cocaine, morphine, quinine, and ephedrine. Ephedrine is a chemical substance present in the leaves of an herb called Ephedra or Ma Huang, which has physiological effects on digestive, heart and blood pressure functions.
How does it work?
You should be familiar with adrenaline. The fight or flight hormone. Noradrelanine is its cousin, and that they both target adrenergic receptors in many cells, in other words, when these substances are released in your body, the adrenergic receptors will react. Ephedrine will cause your heart rate will increase, your pupils will dilate, your blood will be directed to your important muscles. We react to threats or stimuli with a general discharge of the nervous system, urging them to defend or to escape.
The link with ephedrine is because of it being a sympathomimetic alkaloid, ephedrine will work by increasing the activity of noradrenaline on adrenergic receptors. In other words, it will cause your brain to discharge neurotransmitters to some of your cells which will react in an adrenaline rush.
- Increases airflow
- Is a bronchodilator due to its stimulation of beta–2 receptors in the lungs
- Increase blood pressure
- Stimulate thermogenesis which is the heat production of the body, thus higher metabolic rate, increasing energy consumption and fat oxidation
- Decrease gastric emptying
- Improve athletic performance by stimulating the central nervous system and by increasing heart rate and contraction force via activation of the beta-1 receptors
What is the difference between ephedra and ephedrine?
I will keep this simple, Ephedra is the plant and ephedrine is the active ingredient – alkaloid – contained in the leaves.
What is the difference between ephedrine and pseudoephedrine?
They are similar, both are alkaloids present in ephedra’s leaves, pseudoephedrine has a better effect as decongestant but ephedrine is by far better for metabolism.
What is the difference between ephedrine and ephedrine sulfate?
Ephedrine HCL is approximately 82% ephedrine by weight and ephedrine sulfate 77%. Ephedrine sulfate is reported to deliver effects faster than HCL.
Is it legal to buy Ephedrine HCL or Sulfate?
Yes, in most states in the USA where the pressure is high since the FDA ban and all the buzz around pseudoephedrine and methamphetamine, it is still legal to buy ephedrine for personal use such as allergy, flu or asthma treatment. In other words, it is legal to purchase it for hay fever, cold, flu, allergy, asthma and other bronchial conditions, if you have no intent to use it as a drug precursor to manufacture illicit substances. What is illegal for a company (production or distribution) is to promote it as diet pills for weight loss, including the hydrochloride form of course.
The legal quantity purchased per month and per person in the USA is legally limited to 9 grams.
Is ephedrine safe?
An assessment of medical studies is available at the CRN website (Council for Responsible Nutrition), stated that all studies concluded that ephedrine was presenting no risk at the prescribed dosage.
To use ephedrine as bronchodilator you should consult their doctor first in order to check potential contraindications. Avoid buying fake products online, especially sites like ebay and Amazon. If you can buy it without submitting a copy of your photo ID, it is not real ephedrine. Live Lean Today.com has been selling Vasopro Ephedrine HCL 25mg and 12.5 mg for 20 years. I think you can trust this source!
Can Ephedrine HCL Be Used For Allergy Relief and Is It Effective?
Ephedrine has been used from the ancient era to cure cold, seasonal allergies, asthma and also as the main composition of weight loss supplements. Ephedrine is no longer sold as a weight loss supplement because of DEA regulations and the Combat Methamphetamine Act of 2005. Ephedrine has been used, still is used and has increased in use in over the counter
medicine for asthma because it really soothes the respiratory system and improve respiration. These are many of the same symptoms that accompany allergies.
Ephed Ephedrine contains an additional product call Guaifenesin. Guaifenesin is used to treat coughs and congestion caused by the common cold, bronchitis, and other breathing illnesses. It is not for long-term breathing problems (such as chronic bronchitis, emphysema) unless directed by your doctor. Guaifenesin is an expectorant. It works by thinning and loosening mucus in the airways, clearing congestion, and making breathing easier. Once again this is why Ephed works well for Allergy relief.
These products do not cure or shorten the length of the common cold. To decrease the risk for side effects, carefully follow all dosage directions. Do not give other cough-and-cold medication that might contain the same or similar ingredients (see also Drug Interactions section). Ask the doctor or pharmacist about other ways to relieve cough and cold symptoms (such as drinking enough fluids, using a humidifier or saline nose drops/spray).
The other wonderful use of Ephedrine is to cure and prevent seasonal allergies. It is an effective decongestant which is used in curing the cold and allergies. It provides the resistance to fight against the allergies improving immune system. It works great for the asthmatic patients. It widens the respiration area in the lungs and reduces irritation and other breathing issues. It acts as magical drug for the patient suffering from respiratory problems.
One side effect of ephedrine is that it is appetite suppressant. So it is important to make sure you eat properly while taking ephedrine to maintain a healthy immune system.
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As with any OTC medications ask your doctor or pharmacist for more details about using your product safely.
Ischaemic heart disease
Ephedrine has positive inotropic and chronotropic effects on the heart and its use should be avoided in patients with ischaemic heart disease.
Ephedrine increases blood pressure in man. Over the counter acquisition of sympathomimetics should always be considered in hypertensive patients whose blood pressure control has suddenly deteriorated.
Patients with hyperthyroidism may be susceptible to the effects of ephedrine. Ephedrine may precipitate acute urinary retention in patients with prostatic hypertrophy.
Ephedrine should be given with care to patients with hyperthyroidism, diabetes mellitus, angle-closure glaucoma and renal impairment.
Ephedrine has potentially life threatening effects in its acute cardiovascular and central stimulant effects.
Patients with rare hereditary problems of galactose intolerance, the Lapp lactase deficiency or glucose-galactose malabsorption should not take this medicine.
Other adrenoceptor stimulants: Concurrent use of ephedrine with theophylline may result in increased nausea, nervousness, and insomnia.
Anaesthetics: There may be an increased risk of arrhythmias when used with volatile liquid anaesthetics.
Antidepressants: Ephedrine should not be given to patients who are being treated with monoamine oxidase inhibitors as they may cause hypertensive crisis with marked headache, severe hypertension and subarachnoid haemorrhage. Noradrenaline is displaced by ephedrine with the release of large amounts of catecholamine. The interaction may occur up to two weeks after stopping MAOI therapy. There may be an increased risk of arrhythmias when ephedrine is used with tricyclic antidepressants.
Antihypertensives: Loss of blood pressure control has been detected in hypertensive patients undergoing concurrent therapy with ephedrine and adrenergic neurone blocking drugs and may also occur with other antihypertensives.
Antimigraine drugs: Enhanced vasoconstriction and pressor effects with ergotamine or methysergide; concurrent use of ergotamine not recommended (risk of gangrene).
Cardiac glycosides: Increased risk of arrhythmias in patients receiving ephedrine and cardiac glycosides.
Corticosteroids: Ephedrine has been shown to increase the clearance and prolong the half-life of dexamethasone in asthmatic patients.
Oxytocin: Increased risk of vasoconstrictor or pressor effects in patients receiving oxytocin and ephedrine.
Urinary acidifiers/alkalinisers: Effects of ephedrine may be reduced by acidification and increased by alkalinization of the urine.
The use of ephedrine in pregnancy should be avoided as ephedrine crossed the placenta and this has been associated with an increase in foetal heart rate and beat to beat variability. Ephedrine is excreted in breast milk and therefore its use during lactation should be avoided. Irritability and disturbed sleep patterns have been reported in breast fed infants.
The most common side-effects of ephedrine are tachycardia, anxiety, nausea, restlessness and insomnia. Tremor, dry mouth, impaired circulation to the extremities, hypertension, headache and cardiac arrhythmias may occur. Tolerance with dependence has been reported with prolonged administration.
Myocardial infarction has occurred very rarely in patients taking ephedrine or pseudoephedrine.
Ephedrine may act as stimulant in children with nocturnal enuresis and cause sleeplessness. It may have sedative effects in some children.
The elderly are more sensitive to the cardiovascular effects of ephedrine.
Reporting of suspected adverse reactions
Reporting suspected adverse reactions after authorisation of the medicinal product is important. It allows continued monitoring of the benefit/risk balance of the medicinal product. Healthcare professionals are asked to report any suspected adverse reactions via the Yellow Card Scheme at www.mhra.gov.uk/yellowcard.
The symptoms of overdose are normally seen as nausea, vomiting, hypertension, fever, palpitations, tachycardia, restlessness, respiratory depression and convulsions. Paranoid psychosis, delusions and hallucinations may also follow ephedrine overdosage.
In severe overdosage, the stomach should be emptied by emesis and lavage. Management is by supportive symptomatic therapy.
Ephedrine is a sympathomimetic agent with direct and indirect effects on adrenergic receptors.
When given by mouth in therapeutic doses, ephedrine constricts the peripheral vessels, thus increasing blood pressure. It also relaxes bronchioles.
Ephedrine is rapidly and completely absorbed after oral administration and extensively distributed throughout the body with accumulation in the liver, lungs, kidneys, spleen and brain.
Peak plasma concentrations are attained during therapy of 65-120 ug/ml, effective bronchodilator plasma levels are in the range 35-80 ug/ml.
The plasma half-life is reported to be between 3-11 hours, with up to 95% being excreted in the urine.
Studies in mice have shown that the lethal toxicity of ephedrine is increased by elevation of body temperature.
Ephedrine induces acute locomotor stimulatory activity in rats and mice. The estimated lethal dose in children up to 2 years of age is 200mg and for adults 2g. Fatalities are rare and single doses up to 400mg have been given without serious toxic effects.
Polypropylene and polyethylene containers – Three years.
Blister strips – Two years
Do not store above 25°C.
Store in the original container in order to protect from light.
Polypropylene or polyethylene containers with tamper evident closure. Each pack contains 28, 30, 56, 60, 84, 90, 100, 250 or 1000 tablets.
Blister strips of 28, 30, 56, 60, 84, 90 tablets.